A position is open for an experienced in vivo tumour biologist postdoc or clinician scientist, starting in summer 2019.
NanoCapture is a translational research project developing cytotoxic nanoparticle therapeutics, to improve the efficiency and safety margin of cancer therapy. The NanoCapture project is funded by the highly prestigious biennial GOBio Biotechnology award of the BMBF (German Ministry of Education and Research), after prior BMBF support through a Biotechnology Exploratory Grant in 2015 and a Feasibility Grant in 2017. The NanoCapture project is now co-led by Dr. Petar Marinković.
Basis of the project: "Nano-sized" diagnostic and therapeutic agents including nanoparticles, liposomes, quantum dots and virus-like particles have been intensely developed since the 1980s. These concepts are appealing for their potential to deliver high doses of cargo per particle, as well as delivering cargoes that cannot be formulated as small molecules (eg. hydrolytically unstable compounds, elements which cannot easily be included in drugs, or functions reliant on superstructure eg. quantum dots). Yet very little nano work has reached patients in the clinic. A major problem is that nanoparticles have not been sufficiently as well as selectively distributed to tumours, despite the targeting methods tested (including the EPR effect or decoration with cell-surface-receptor ligands / antibodies).
We are exploring a new combination approach using traditional organic chemistry to shunt nanoparticles into tumours with faster delivery, higher dose accumulation, and higher tumour selectivity than nanoparticle-only methods. We aim to apply this to arbitrary nano-formulated cargoes (diagnostic agents for MRI, PET, or fluorescence; therapeutic agents; or theranostic particles), allowing medical applications for a range of nano-systems which have already been developed: both for early-diagnostic purposes, and for therapeutic anticancer use.