The Thorn-Seshold Research Group: Chemical Biology
We use organic chemistry to create chemical biology reagents solving problems in cell biology and translational therapy.
Our lab members have diverse backgrounds in chemistry, pharmaceutical sciences and biology, and work together to transition our molecules and techniques across the traditional divides between these areas. Researchers will find a flexible and interdisciplinary environment to master new skills from organic synthesis and cell biology to in vivo biology.
Basic research into novel methods for selectively targeting bioactivity is the keystone of our group. We are supported by the DFG to work on several biochemical targets, through an Emmy Noether grant (photochemical tools for tubulin biology) and through DFG consortia SFB1032 (spatiotemporal control in biophysical networks), SFB152 (chemical biology tools for TRP channels) and SPP1926 (next-generation photopharmacology and optogenetics tools).
Translating our research to real-world application is also an important goal for us, and we are running two preclinical projects applying our methods to oncology. The CytoSwitch project, supported by the competitive EXIST-Forschungstransfer grant, is evaluating photoswitchable compounds for cancer therapy; and the NanoCapture project, supported by the prestigious GO-Bio grant, is testing a method to selectively deliver nanoformulated therapeutics.
We are an independent research group hosted at the Pharmacy Dept by the Chair of Pharmaceutical/Medicinal Chemistry (Prof. K. T. Wanner).