Thorn-Seshold Group: Chemical Biology and Pharmaceutical Chemistry
We use novel organic chemistry and chemical biology to address problems in cell biology and translational therapy.
Our lab members have diverse backgrounds in chemistry, pharmaceutical sciences and biology, and work together to transition our new molecules and techniques across the traditional divides between these areas. Researchers will find a flexible and interdisciplinary environment to master new skills in organic synthesis, cell biology, biochemistry, microscopy, photochemistry, and in vivo biology.
Basic research into novel methods for selectively targeting bioactivity is the keystone of our group, and we are supported by the DFG (Emmy Noether grant, SFB1032 and SFB152 consortia) to work on several biochemical targets.
However, translating this research towards real-world applications is an important goal for us, and we are strongly supported by the German government to conduct two preclinical testing projects. The CytoSwitch project, supported by the competitive EXIST-Forschungstransfer grant, is evaluating photoswitchable compounds for cancer therapy; and the NanoCapture project, supported by the prestigious GO-Bio grant, is testing a method to selectively deliver nanoformulated therapeutics - again for cancer therapy.
The NanoCapture project recently won GOBio funding to support an ambitious translational research effort (April 2018)
We are an independent research group established in 2016 with the assistance of Prof. Klaus T. Wanner.