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Publications

Career

20. U Theisen, A Ernst, R Heyne, T Ring, O Thorn-Seshold, R Köster; Microtubules and motor proteins support zebrafish neuronal migration by directing cargo. Journal of Cell Biology 2020, in press.
19. M Borowiak, F Küllmer, F Gegenfurtner, S Peil, V Nasufovic, S Zahler, O Thorn-Seshold, D Trauner, H-D Arndt; Optical manipulation of F-actin with photoswitchable small molecules. Journal of the American Chemical Society 2020, 142, 9240.

O Thorn-Seshold*; Comment on “Photo-Controlled Reversible Microtubule Assembly Mediated by Paclitaxel-Modified Cyclodextrin”. Angewandte Chemie 2020, 59, 7652 (critique to Liu et al., ACIE 2018 in light of nonspecificity wrt Liu et al., ACIE 2019; response here, issue ongoing).

18. A Müller-Deku, K Loy, Y Kraus, C Heise, R Bingham, J Ahlfeld, D Trauner*, O Thorn-Seshold*; Photoswitchable microtubule stabilisers optically control tubulin cytoskeleton structure and function. preprint at bioRxiv 2019.09.22, 10.1101/778993.
17. Y Kraus#, C Glas#, B Melzer, L Gao, C Heise, M Preuße, J Ahlfeld, F Bracher, O Thorn-Seshold*; Isoquinoline-based biaryls as a robust scaffold for microtubule inhibitors. European Journal of Medicinal Chemistry 2020, 186, 111865.
16. A Sailer, F Ermer, Y Kraus, R Bingham, F Lutter, J Ahlfeld and O Thorn-Seshold*; Potent hemithioindigo-based antimitotics photocontrol the microtubule cytoskeleton in cellulo. Beilstein Journal of Organic Chemistry 2020, 16, 125.
15. L Gao, Y Kraus, M Wranik, T Weinert, S Pritzl, J Meiring, R Bingham, N Olieric, A Akhmanova, T Lohmüller, M Steinmetz, and O Thorn-Seshold*; Photoswitchable microtubule inhibitors enabling robust, GFP-orthogonal optical control over the tubulin cytoskeleton. preprint at bioRxiv 2019.07.27, 10.1101/716233.
14. A Kopf, J Renkawitz, R Hauschild, I Girkontaite, K Tedford, J Merrin, O Thorn-Seshold, D Trauner, H Häcker, K-D Fischer, E Kiermaier and M Sixt; Microtubules control cellular shape and coherence in amoeboid migrating cells. Journal of Cell Biology 2020, 219, e201907154.
13. A Sailer, F Ermer, Y Kraus, F Lutter, C Donau, M Bremerich, J Ahlfeld and O Thorn-Seshold*; Hemithioindigos for cellular photopharmacology: desymmetrised molecular switch scaffolds enabling design control over the isomer-dependency of potent antimitotic bioactivity. ChemBioChem 2019, 20, 1305-1314.
12. O Thorn-Seshold*, F. Bracher, B. Melzer; Isoquinoline biaryl compounds. EP18207030, 2018.
11. A Singh, T Saha, I Begemann, A Ricker, H Nüsse, O Thorn-Seshold, J Klingauf, M Galic, M Matis*; Polarized microtubule dynamics directs cell mechanics and coordinates forces during epithelial morphogenesis. Nature Cell Biology 2018, 20, 1126-1133.
10. J Zenker, MD White, RM Templin, RG Parton, O Thorn-Seshold, S Bissiere, N Plachta*; A microtubule-organizing center directing intracellular transport in the early mouse embryo. Science 2017, 357, 925-928.
9. K Eguchi, Z Taoufiq, O Thorn-Seshold, et al., T Takahashi*; Wild-type monomeric α-synuclein can impair vesicle endocytosis and synaptic fidelity via tubulin polymerization at the calyx of Held. The Journal of Neuroscience 2017, 37, 6043-6052.
8. M Borowiak, et al., D Trauner*, O Thorn-Seshold*; Photoswitchable Inhibitors of Microtubule Dynamics Optically Control Mitosis and Cell Death. Cell 2015, 162, 403-411.
7. O Thorn-Seshold*, M Borowiak, D Trauner, J Hasserodt; Azoaryls as Reversibly Modulatable Tubulin Inhibitors. WO2015166295, 2014.

Studies & PhD

6. O Thorn-Seshold, M Vargas-Sanchez, S McKeon, J Hasserodt; A Robust, High-Sensitivity Stealth Probe for Peptidases. Chem. Comm. 2012, 48, 6253-6255.

5. J Hasserodt, O Thorn-Seshold; Fluorogenic Peptidase Substrate. WO2013045854, 2011.

4. D Konkolewicz, O Thorn-Seshold and A Gray-Weale; Models for randomly hyperbranched polymers: Theory and simulation. J. Chem. Phys. 2008, 129, 054901.

3. MM Bishop, LF Lindoy, M McPartlin, A Parkin, O Thorn-Seshold, P Turner; A systematic study of ligand intermolecular interactions in crystals of copper(II) complexes of bidentate guanidino derivatives. Polyhedron 2007, 26, (2), 415-429.

2. MM Bishop, SJ Coles, A Lee, LF Lindoy, A Parkin, O Thorn-Seshold, P Turner; A Structural Study of Tautomerism and Hydrogen-Bonding in Supramolecular Assemblies. Supramol. Chem. 2005, 17, (7), 567-578.

1. MM Bishop, LF Lindoy, O Thorn-Seshold, RO Piltz, P Turner; A Supramolecular Assembly Containing an Unusually Short N-H∙∙∙N Hydrogen Bond. J. Het. Chem. 2001, 38, (6), 1377-1382.